Sildenafity Citrate equivalent to Sildenafil 50 mg
Ozomen an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine mono-phosphate (cGMP)-specific phosphodiesterase type5 (PDE5). Slidenafil citrate is designated chemically as 1-[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-dypyrimidin-5-yl)-4-ethoxyphenyl) sulfonyl]-4-methylpiperazine citrate and has a molecular weight of 6667.
Mechanism of action
The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavemosum during sexual stimulation, NO then activates the enzyme guanlate cyclase, which results in increased levels of cyclic guanosine monophosphate (CGMP), producing smooth muscle relaxation in the corpus cavemosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavemosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of CGMP in the corpus cavemosum.
Sildenafil citrate is rapidly absorbed after oral administration, with an absolute bioavailability of about 40%. Its pharmacoki netics are doseproportional over the recommended dose range. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state.When sildenafil citrate is taken with a high fat meat, the rate of absorption is reduced, with a mean delay. In Tmax of 60 minutes and a mean reduction in Cmax of 29%. The mean steady state volume of distribution (Vss) for Sildenafil is 105L, indicating distribution into the tissues.